Activation of the mesolimbic dopamine reward pathway by acute ethanol produces
reinforcement and changes in gene expression that appear to be crucial to the molecular …

Background Individual differences in initial sensitivity to ethanol are strongly related to the
heritable risk of alcoholism in humans. To elucidate key molecular networks that modulate …

Sensitivity to ethanol intoxication, propensity to drink ethanol and vulnerability to develop
alcoholism are all influenced by genetic factors. Conversely, exposure to ethanol or …

Neuroadaptations that participate in the ontogeny of alcohol dependence are likely a result
of altered gene expression in various brain regions. The present study investigated brain …

Mice that exhibit characteristics of physical dependence following ethanol exposure serve
as useful models of alcoholism in humans. The DBA/2 J and C57BL/6 J inbred strains differ …

Long lasting abusive consumption, dependence, and withdrawal are characteristic features
of alcohol use disorders (AUD). Mechanistically, persistent changes in gene expression are …

Genetic analysis of factors affecting risk to develop excessive ethanol drinking has been
extensively studied in humans and animal models for over 20 years. However, little progress …

Background: Ethanol addiction has been conceptualized as a progression from occasional,
impulsive use to compulsive behavior. Ethanol‐dependence is a chronic pathology with …

The objective of this study was to determine time-course changes in gene expression within
two regions of the extended amygdala after binge-like alcohol drinking by alcohol-preferring …

Background Alcohol dependence (AD) shows evidence for genetic liability, but genes
influencing risk remain largely unidentified. Methods We conducted a genomewide …