Potential of erlotinib cyclodextrin nanosponge complex to enhance solubility, dissolution rate, in vitro cytotoxicity and oral bioavailability

CP Dora, F Trotta, V Kushwah, N Devasari… - Carbohydrate …, 2016 - Elsevier
The present study was envisaged to evaluate the effect of erlotinib β-cyclodextrin
nanosponge (ERL-NS) on the solubility, dissolution, in vitro cytotoxicity and oral …

Inclusion complex of erlotinib with sulfobutyl ether-β-cyclodextrin: Preparation, characterization, in silico, in vitro and in vivo evaluation

N Devasari, CP Dora, C Singh, SR Paidi, V Kumar… - Carbohydrate …, 2015 - Elsevier
The aim of the study was to investigate the impact of erlotinib sulfobutyl ether beta-
cyclodextrin complex (ERL-SBE-β-CD) on ERL dissolution rate and oral bioavailability …

Extended release delivery of erlotinib glutathione nanosponge for targeting lung cancer

MM Momin, Z Zaheer, R Zainuddin… - Artificial cells …, 2018 - Taylor & Francis
Systemic and uncontrolled administration of erlotinib hydrochloride (ETB) is associated with
severe toxicity. A novel targeted and extended release nanosponge (NS) was synthesized …

Cyclodextrin modified erlotinib loaded PLGA nanoparticles for improved therapeutic efficacy against non-small cell lung cancer

B Vaidya, V Parvathaneni, NS Kulkarni… - International journal of …, 2019 - Elsevier
This study was aimed at developing a nanoparticle strategy to overcome acquired
resistance against erlotinib in non-small cell lung cancer (NSCLC). To load erlotinib on …

Enhanced stability and oral bioavailability of erlotinib by solid self nano emulsifying drug delivery systems

S Jain, K Dongare, B Nallamothu, CP Dora… - International Journal of …, 2022 - Elsevier
The present investigation demonstrates the preparation of solid self nanoemulsfying drug
delivery system (sSNEDDS) to enhance stability and bioavailability of Erlotinib (ERL) via the …

[HTML][HTML] Development of solid self-emulsifying formulation for improving the oral bioavailability of erlotinib

DH Truong, TH Tran, T Ramasamy, JY Choi, HH Lee… - Aaps Pharmscitech, 2016 - Springer
To improve the solubility and oral bioavailability of erlotinib, a poorly water-soluble
anticancer drug, solid self-emulsifying drug delivery system (SEDDS) was developed using …

Preparation and characterization of cyclodextrin nanosponges for bortezomib delivery

S Allahyari, H Valizadeh, L Roshangar… - Expert Opinion on …, 2020 - Taylor & Francis
Background Bortezomib (BTZ) as an anticancer drug has been used through the injection
pathway. Research design and methods Two types of Cyclodextrin nanosponges (CDNSs) …

[HTML][HTML] Cyclodextrin nanosponge for the GSH-mediated delivery of Resveratrol in human cancer cells

M Palminteri, NK Dhakar, A Ferraresi, F Caldera… - …, 2021 - ncbi.nlm.nih.gov
Smart drug delivery systems are required for the site-specific drug targeting to enhance the
therapeutic efficiency of a drug. Resveratrol (RV) is a polyphenolic compound with anti …

Core-shell structured pullulan based nanocomposites as erlotinib delivery shuttles

H Bera, SR Ang, SW Chiong, CH Chan… - … Journal of Polymeric …, 2020 - Taylor & Francis
Anionic biopolymer (sodium alginate/low-methoxyl pectin/gellan gum) coated carboxymethyl
pullulan-ZnO nanocomposites encapsulating erlotinib were developed for lung cancer …

Nintedanib-cyclodextrin complex to improve bio-activity and intestinal permeability

B Vaidya, SK Shukla, S Kolluru, M Huen, N Mulla… - Carbohydrate …, 2019 - Elsevier
Cyclodextrin complex of nintedanib was prepared aiming for increased bio-activity and
improved transport across intestinal membrane with reduced p-glycoprotein (p-gp) efflux …