Thiosulfate mediates cytoprotective effects of hydrogen sulfide against neuronal ischemia

E Marutani, M Yamada, T Ida, K Tokuda… - Journal of the …, 2015 - Am Heart Assoc
Background Hydrogen sulfide (H2S) exhibits protective effects in various disease models
including cerebral ischemia–reperfusion (I/R) injury. Nonetheless, mechanisms and identity …

Hydrogen sulfide protects the brain against ischemic reperfusion injury in a transient model of focal cerebral ischemia

S Gheibi, N Aboutaleb, M Khaksari… - Journal of Molecular …, 2014 - Springer
Abstract Hydrogen sulfide (H 2 S), a well-known toxic gas, is regarded as endogenous
neuromodulator and plays multiple roles in the central nervous system under physiological …

Vascular protection of hydrogen sulfide on cerebral ischemia/reperfusion injury in rats

JY Wen, M Wang, YN Li, HH Jiang, XJ Sun… - Frontiers in …, 2018 - frontiersin.org
This study was undertaken to demonstrate the vascular protection of exogenous and
endogenous hydrogen sulfide (H2S) on cerebral ischemia/reperfusion (I/R) injury. The effect …

Protective effects of exogenous hydrogen sulfide on neurons of hippocampus in a rat model of brain ischemia

Z Li, Y Wang, Y Xie, Z Yang, T Zhang - Neurochemical Research, 2011 - Springer
Many studies have demonstrated the cytoprotective effects of hydrogen sulfide (H 2 S) in
vitro and/or in vivo ischemic injury. The aim of the current study was to investigate whether …

Exogenous Hydrogen Sulfide Offers Neuroprotection on Intracerebral Hemorrhage Injury Through Modulating Endogenous H2S Metabolism in Mice

H Shan, J Qiu, P Chang, Y Chu, C Gao… - Frontiers in Cellular …, 2019 - frontiersin.org
Hydrogen sulfide (H2S), an important endogenous signaling molecule, has a significant
neuroprotective role in the central nervous system. In this study, we examined the protective …

Hydrogen sulfide ameliorates early brain injury following subarachnoid hemorrhage in rats

Y Cui, X Duan, H Li, B Dang, J Yin, Y Wang… - Molecular …, 2016 - Springer
Increasing studies have demonstrated the neuroprotective effect of hydrogen sulfide (H 2 S)
in central nervous system (CNS) diseases. However, the potential application value of H 2 S …

Exogenous hydrogen sulfide protects against global cerebral ischemia/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats

J Yin, C Tu, J Zhao, D Ou, G Chen, Y Liu, X Xiao - Brain research, 2013 - Elsevier
The present study was undertaken to study the effects of exogenous hydrogen sulfide (H2S)
on global cerebral ischemia–reperfusion (I/R) and the underlying mechanisms. After a 24h …

Hydrogen sulfide reduces ischemia and reperfusion injury in neuronal cells in a dose-and time-dependent manner

S Scheid, M Goeller, W Baar, J Wollborn… - International journal of …, 2021 - mdpi.com
Background: The ischemia-reperfusion injury (IRI) of neuronal tissue, such as the brain and
retina, leads to possible cell death and loss of function. Current treatment options are limited …

Protective effects of hydrogen sulfide in a rat model of traumatic brain injury via activation of mitochondrial adenosine triphosphate–sensitive potassium channels and …

X Jiang, Y Huang, W Lin, D Gao, Z Fei - journal of surgical research, 2013 - Elsevier
Abstract Background Hydrogen sulfide (H 2 S) is considered an important neuromodulator in
the central nervous system. We designed the present study to investigate the effects of …

[HTML][HTML] Hydrogen sulfide and its donors for the treatment of cerebral ischaemia-reperfusion injury: A comprehensive review

Y Huang, M Omorou, M Gao, C Mu, W Xu… - Biomedicine & …, 2023 - Elsevier
As an endogenous gas signalling molecule, hydrogen sulfide (H 2 S) is frequently present in
a variety of mammals and plays a significant role in the cardiovascular and nervous systems …