Genome activation in bovine embryos: review of the literature and new insights from RNA sequencing experiments

A Graf, S Krebs, M Heininen-Brown… - Animal reproduction …, 2014 - Elsevier
Maternal-to-embryonic transition (MET) is the period in early embryonic development when
maternal RNAs and proteins stored in the oocyte are gradually degraded and transcription …

Fine mapping of genome activation in bovine embryos by RNA sequencing

A Graf, S Krebs, V Zakhartchenko… - Proceedings of the …, 2014 - National Acad Sciences
During maternal-to-embryonic transition control of embryonic development gradually
switches from maternal RNAs and proteins stored in the oocyte to gene products generated …

[PDF][PDF] Unveiling the bovine embryo transcriptome during the maternal-to-embryonic transition

C Vigneault, C Gravel, M Vallée, S McGraw… - …, 2009 - researchgate.net
Bovine early embryos are transcriptionally inactive and subsist through the initial
developmental stages by the consumption of the maternal supplies provided by the oocyte …

Dynamics of global transcriptome in bovine matured oocytes and preimplantation embryos

M Misirlioglu, GP Page, H Sagirkaya… - Proceedings of the …, 2006 - National Acad Sciences
Global activation of the embryonic genome is the most critical event in early mammalian
development. After fertilization, a rich supply of maternal proteins and RNAs support …

[HTML][HTML] Single-cell RNA sequencing reveals developmental heterogeneity of blastomeres during major genome activation in bovine embryos

I Lavagi, S Krebs, K Simmet, A Beck… - Scientific reports, 2018 - nature.com
Embryonic development is initially controlled by maternal RNAs and proteins stored in the
oocyte, until gene products gradually generated by the embryo itself take over. Major …

Genome-wide expression profiling reveals distinct clusters of transcriptional regulation during bovine preimplantation development in vivo

WA Kues, S Sudheer, D Herrmann… - Proceedings of the …, 2008 - National Acad Sciences
Bovine embryos can be generated by in vitro fertilization or somatic nuclear transfer;
however, these differ from their in vivo counterparts in many aspects and exhibit a higher …

Molecular mechanisms and pathways involved in bovine embryonic genome activation and their regulation by alternative in vivo and in vitro culture conditions

A Gad, M Hoelker, U Besenfelder… - Biology of …, 2012 - academic.oup.com
Understanding gene expression patterns in response to altered environmental conditions at
different time points of the preimplantation period would improve our knowledge on …

Gene expression profiling of single bovine embryos uncovers significant effects of in vitro maturation, fertilization and culture

SL Smith, RE Everts, LY Sung, F Du… - Molecular …, 2009 - Wiley Online Library
In vitro production (IVP) has been shown to affect embryonic gene expression and often
result in large offspring syndrome (LOS) in cattle and sheep. To dissect the effects of in vitro …

Identification of differentially regulated genes in bovine blastocysts using an annealing control primer system

KC Hwang, XS Cui, SP Park, MR Shin… - Molecular …, 2004 - Wiley Online Library
The identification of embryo‐specific genes would provide insights into early embryonic
development. However, the current methods employed to identify the genes that are …

[HTML][HTML] Transcriptional profiles of bovine in vivo pre-implantation development

Z Jiang, J Sun, H Dong, O Luo, X Zheng, C Obergfell… - BMC genomics, 2014 - Springer
Background During mammalian pre-implantation embryonic development dramatic and
orchestrated changes occur in gene transcription. The identification of the complete changes …