Radiotherapy—despite being a local therapy that meanwhile is characterized by an
impressively high degree of spatial accuracy—can stimulate systemic phenomena which …

Radiotherapy has been used for more than a hundred years to cure or locally control tumors.
Regression of tumors outside of the irradiated field was occasionally observed and is known …

Radiotherapy has been used for more than a hundred years as a local tumor treatment. The
occurrence of systemic antitumor effects manifesting as regression of tumors outside of the …

Background Recently, immunologic responses to localized irradiation are proposed as
mediator of systemic effects after localized radiotherapy (called the abscopal effect). Here …

The abscopal effect is mediated by a systemic anti-tumor immune response and reflects the
regression of non-irradiated metastatic lesions at a distance from the primary site of …

The concept of utilizing localized radiation therapy to elicit out-of-target tumor responses—
the abscopal effect—was proposed over 50 years ago (1, 2). Over the past decades, the …

For over a century, ionising radiation has been used to treat cancer based on its cytotoxic
effects on tumour cells. Technical progress has enabled more precise targeting of the …

More than 60 years ago, the effect whereby radiotherapy at one site may lead to regression
of metastatic cancer at distant sites that are not irradiated was described and called the …

Ionising radiation (IR) may harm cancer cells through a rare indirect out-of-field
phenomenon described as the abscopal effect. Increasing evidence demonstrates that …

An 'abscopal'effect if often used to refer to distant tumour regression after localised
irradiation. Since the first report of the abscopal effect in the 1950s, well-documented cases …