Induction of abscopal anti-tumor immunity and immunogenic tumor cell death by ionizing irradiation-implications for cancer therapies
B Frey, Y Rubner, R Wunderlich… - Current medicinal …, 2012 - ingentaconnect.com
Although cancer progression is primarily driven by the expansion of tumor cells, the tumor
microenvironment and anti-tumor immunity also play important roles. Herein, we consider …
microenvironment and anti-tumor immunity also play important roles. Herein, we consider …
[HTML][HTML] Abscopal effect of radiotherapy in the immunotherapy era: systematic review of reported cases
N Dagoglu, S Karaman, HB Caglar, EN Oral - Cureus, 2019 - ncbi.nlm.nih.gov
Mounting evidence suggests that radiation stimulates the immune system and this
contributes to the abscopal effect, which is defined as “response at a distance from the …
contributes to the abscopal effect, which is defined as “response at a distance from the …
Immune mechanisms mediating abscopal effects in radioimmunotherapy
ME Rodriguez-Ruiz, I Rodriguez, O Leaman… - Pharmacology & …, 2019 - Elsevier
Radiotherapy of cancer has been traditionally considered as a local therapy without
noticeable effects outside the irradiated fields. However, ionizing radiation exerts multiple …
noticeable effects outside the irradiated fields. However, ionizing radiation exerts multiple …
Radiation, immune checkpoint blockade and the abscopal effect: a critical review on timing, dose and fractionation
The combination of radiation and immunotherapy is currently an exciting avenue of pre-
clinical and clinical investigation. The synergy between these two treatment modalities has …
clinical and clinical investigation. The synergy between these two treatment modalities has …
Radiation as an in situ auto-vaccination: current perspectives and challenges
T Goto - Vaccines, 2019 - mdpi.com
Radiotherapy is generally considered to be a local treatment, but there have been reports of
rare cases demonstrating abscopal effects in which antitumor effects have been observed in …
rare cases demonstrating abscopal effects in which antitumor effects have been observed in …
[HTML][HTML] A review of the abscopal effect in the era of immunotherapy
E Nabrinsky, J Macklis, J Bitran - Cureus, 2022 - ncbi.nlm.nih.gov
The abscopal effect is a systemic immune response mediated by the effects of radiation on
the immune system. This effect has been observed in a number of cancer types in addition to …
the immune system. This effect has been observed in a number of cancer types in addition to …
Combining radiation and immunotherapy: a new systemic therapy for solid tumors?
With the recent success of checkpoint inhibitors and other immunomodulating agents, there
has been renewed interest in the combination of such agents with radiation. The biologic …
has been renewed interest in the combination of such agents with radiation. The biologic …
Abscopal effect of radiotherapy combined with immune checkpoint inhibitors
Y Liu, Y Dong, L Kong, F Shi, H Zhu, J Yu - Journal of hematology & …, 2018 - Springer
Radiotherapy (RT) is used routinely as a standard treatment for more than 50% of patients
with malignant tumors. The abscopal effect induced by local RT, which is considered as a …
with malignant tumors. The abscopal effect induced by local RT, which is considered as a …
Radiotherapy and immunotherapy for cancer: from “systemic” to “multisite”
A Arina, SI Gutiontov, RR Weichselbaum - Clinical Cancer Research, 2020 - AACR
In the era of cancer immunotherapy, there is significant interest in combining conventional
cancer therapies, such as radiotherapy, with drugs that stimulate the immune system. The …
cancer therapies, such as radiotherapy, with drugs that stimulate the immune system. The …
Radiation therapy to convert the tumor into an in situ vaccine
SC Formenti, S Demaria - International journal of radiation oncology …, 2012 - redjournal.org
Over the past several months, new examples of the abscopal effects of radiation therapy
have added to the existing literature on this subject and have demonstrated an association …
have added to the existing literature on this subject and have demonstrated an association …