The abscopal effect is a phenomenon in which local radiotherapy is associated with the
regression of metastatic cancer at a distance from the irradiated site. The abscopal effect …

Simple Summary This review presents and summarizes the key components and outcomes
of a novel, unconventional radiation approach aimed to exploit immune-stimulatory radiation …

The abscopal effect following ionizing radiation therapy (RT) is considered to be a rare
event. This effect does occur more frequently when combined with other therapies, including …

Preclinical and clinical evidence indicate that the proimmune effects of radiotherapy can be
synergistically augmented with immunostimulatory mAbs to act both on irradiated tumor …

The abscopal effect of radiation describes tumor regression in metastases outside of the
field upon treatment of one site, and is mediated by radiation-induced anti-tumor T cells. The …

Radiation therapy controls local disease but also prompts the release of tumor-associated
antigens and stress-related danger signals that primes T cells to promote tumor regression …

Radiotherapy has extensively been employed as a curative or palliative intervention against
cancer throughout the last century, with a varying degree of success. For a long time, the …

Radiation is a primary modality in cancer treatment. Radiation can also reduce tumor growth
outside the treatment field, often referred to as the abscopal effect. The mechanisms and …

Considerable interest is being directed toward combining immune-checkpoint inhibition (ICI)
with radiotherapy to improve response rates to ICI, which have been disappointingly low at …

Radiotherapy (RT) is currently used in more than 50% of cancer patients during the course
of their disease in the curative, adjuvant or palliative setting. RT achieves good local control …