Radiation therapy (RT) in some cases results in a systemic anticancer response known as
the abscopal effect. Multiple hypotheses support the role of immune activation initiated by …

Purpose: This study tested the hypothesis that the type of dose fractionation regimen
determines the ability of radiotherapy to synergize with anti–CTLA-4 antibody. Experimental …

Tumors grow progressively when they escape from immune surveillance. Cancer
progression is mainly driven by the expansion of tumor cells, but tumor microenvironment …

Purpose: Localized radiotherapy can cause T-cell–mediated abscopal effects on
nonirradiated metastases, particularly in combination with immune checkpoint blockade …

In a recent issue of Cell Death and Differentiation, Ko and colleagues investigated how the
genetic inhibition of autophagy would impact on the response of human and murine lung …

It remains unclear how localized radiotherapy for cancer metastases can occasionally elicit
a systemic antitumor effect, known as the abscopal effect, but historically, it has been …

Radiotherapy (RT) primarily aims to locally destroy the tumor via the induction of DNA
damage in the tumor cells. However, the so-called abscopal, namely systemic and immune …

The clearance of nonirradiated tumors after localized radiation therapy is known as the
abscopal effect. Activation of an antitumor immune response has been proposed as a …

Ionizing radiation has historically been used to treat cancer by killing tumour cells, in
particular by inducing DNA damage. This view of radiotherapy (RT) as a simple cytotoxic …

Radiotherapy (RT) with ionizing irradiation is commonly used to locally attack tumors. It
induces a stop of cancer cell proliferation and finally leads to tumor cell death. During the …