Background In the last years, limited studies have described that radiotherapy could
produce important distant responses in unirradiated sites, the so-called “abscopal effect” …

Purpose The abscopal effect is defined when a form of local therapy causes tumor
regression of both the target lesion and any untreated tumors. Herein cases of the abscopal …

The therapy of cancer emerged as multimodal treatment strategy. The major mode of action
of locally applied radiotherapy (RT) is the induction of DNA damage that triggers a network …

Purpose Hypofractionated radiation therapy (hRT) combined with immune checkpoint
blockade can induce T-cell–mediated local and abscopal antitumor effects. We had …

Advances in understanding the mechanisms that underlie the interplay between radiation-
invoked immune responses and tumor regression are underway. Emerging applications of …

Background Radiotherapy (RT) has been shown to stimulate an antitumor immune response
in irradiated tumors as well as unirradiated distant sites (abscopal effect). Previous studies …

In cancer patients undergoing radiation therapy, the beneficial effects of radiation can
extend beyond direct cytotoxicity to tumor cells. Delivery of localized radiation to tumors …

Recent advancement in the radiotherapy technology has allowed conformal delivery of high
doses of ionizing radiation precisely to the tumors while sparing large volume of the normal …

PURPOSE: Ionizing radiation can reduce tumor growth outside the field of radiation, known
as the abscopal effect. Although it has been reported in multiple malignancies, the abscopal …

The ability of ionizing radiation to cause cell death and inflammatory reactions has been
known since the beginning of its therapeutic use in oncology. However, only recently this …