The ability of ionizing radiation to cause cell death and inflammatory reactions has been
known since the beginning of its therapeutic use in oncology. However, only recently this …

Recently, modern therapies involving immune checkpoint inhibitors, cytokines, and oncolytic
virus have been developed. Because of the limited treatment effect of modern therapy alone …

In oncology, the “abscopal effect” refers to the therapeutic effect on a distant tumor resulting
from the treatment of local tumor (eg, ablation, injection, or radiation). Typically associated …

A posteriori evidence suggests that radiotherapy to a targeted tumor can elicit an immune-
mediated abscopal (ab-scopus, away from the target) effect in nontargeted tumors, when …

Current efforts combining immunotherapy and radiation have focused on high-dose
radiation delivered to few tumor lesions, aiming to generate diffuse abscopal effects; …

New and innovative treatment strategies for cancer patients in the fields of immunotherapy
and radiotherapy are rapidly developing in parallel. Among the most promising preclinical …

Purpose Research to elucidate predictive factors of the abscopal effect is an essential first
step toward potentially modifying these factors to increase the incidence of systemic …

Background Preclinical in vivo studies using small animals are considered crucial in
translational cancer research and clinical implementation of novel treatments. This is of …

Clinical results indicate improved survival in poorly differentiated prostate cancer patients
following a treatment schedule that maximizes hormone therapy prior to radiation. This may …

Radiation therapy (RT) is a well-established but still under optimization branch of Cancer
Therapy (CT). RT uses electromagnetic waves or charged particles in order to kill malignant …