Vitamin D3 is the precursor of the steroid hormone calcitriol (1α, 25-dihydroxyvitamin D3), a
potent agonist of the transcription factor vitamin D receptor (VDR). Calcitriol has received …

Research carried out during the past two-decades extended the understanding of actions of
vitamin D, from regulating calcium and phosphate absorption and bone metabolism to many …

Under normal circumstances, vitamin D is mainly obtained from skin through the action of
ultraviolet B irradiation on 7-dehydrocholesterol. It is further metabolized to 25 …

Vitamin D 3 is produced non-enzymatically when the cholesterol precursor 7-
dehydrocholesterol is exposed to UV-B, ie, evolutionary the first function of the molecule was …

The immune system, innate and adaptive, is a highly evolved and complex network,
essential for promoting survival in an environment full of potential pathogens, while …

Abstract Purpose of Review In addition to the actions of the endocrine hormone, 1alpha, 25-
dihydroxyvitamin D (1, 25 (OH) 2 D) in stimulating intestinal calcium absorption, the …

Vitamin D is a fat-soluble vitamin and a steroid hormone that plays a central role in
maintaining calcium-phosphorus and bone homeostasis in close interaction with parathyroid …

The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

The discovery of the dual origin of vitamin D either by synthesis in the skin from 7-
dehydrocholesterol under the influence of UVB sunlight or from dietary origin quickly …

Vitamin D, a fat-soluble prohormone, is synthesised in response to sunlight. Vitamin D
requires two metabolic conversions, 25-hydroxylation in the liver and 1a-hydroxylation in the …