The current regimens used to treat tuberculosis are largely comprised of serendipitously
discovered drugs that are combined based on clinical experience. Despite curing millions …

The development of optimal treatment regimens in tuberculosis (TB) remains challenging
due to the need of combination therapy and possibility of pharmacodynamic (PD) …

Current tuberculosis (TB) treatment is based on a combination of drugs that were developed
mostly in the central decades of the last century. Cure rates are high for drug sensitive …

The recent years have witnessed significant progress in the development of new drug
candidates for the treatment of TB. While many of these are now in clinical trials, continued …

In this chapter, we review the history of tuberculosis (TB) chemotherapy along with the
mechanisms of action of important drugs against Mycobacterium tuberculosis. We discuss …

Integrated computational approaches for Mycobacterium tuberculosis (Mtb) are useful to
identify new molecules that could lead to future tuberculosis (TB) drugs. Our approach uses …

A critical unmet need for treatment of drug-resistant tuberculosis (TB) is to find novel
therapies that are efficacious, safe, and shorten the duration of treatment. Drug discovery …

Diagnostic development must occur in parallel with drug development to ensure the
longevity of new treatment compounds. Despite an increasing number of novel and …

Tuberculosis (TB) drug discovery and development has undergone nothing short of a
revolution over the past 20 years. Successful public–private partnerships and sustained …

New drugs that retain potency against multidrug/extensively drug-resistant strains of
Mycobacterium tuberculosis, with the additional benefit of a shortened treatment duration …