Osteoarthritis: toward a comprehensive understanding of pathological mechanism
Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …
Molecular regulation of articular chondrocyte function and its significance in osteoarthritis
JP Schroeppel, JD Crist, HC Anderson… - … and histopathology, Vol …, 2011 - digitum.um.es
Osteoarthritis (OA) is the most common form of joint disease. Histopathologically, OA is
characterized by a progressive loss of articular cartilage, osteophyte formation, thickening of …
characterized by a progressive loss of articular cartilage, osteophyte formation, thickening of …
Osteoarthritis and cartilage regeneration: Focus on pathophysiology and molecular mechanisms
S Grässel, A Aszodi - International Journal of Molecular Sciences, 2019 - mdpi.com
Osteoarthritis (OA) is a leading cause of disability and source of societal cost in older adults.
It is a whole-joint disease in which all components of the joint are affected involving …
It is a whole-joint disease in which all components of the joint are affected involving …
Chondrocyte aging: the molecular determinants and therapeutic opportunities
Osteoarthritis (OA) is a joint degenerative disease that is an exceedingly common problem
associated with aging. Aging is the principal risk factor for OA, but damage-related …
associated with aging. Aging is the principal risk factor for OA, but damage-related …
Probing the communication patterns of different chondrocyte subtypes in osteoarthritis at the single cell level using pattern recognition and manifold learning
J Wang, C Liu, L Yang, H Chen, M Zheng, Y Wan… - Scientific Reports, 2023 - nature.com
The patterns of communication among different chondrocyte subtypes in human cartilage
degeneration and regeneration help us understand the microenvironment of osteoarthritis …
degeneration and regeneration help us understand the microenvironment of osteoarthritis …
Etiopathogenesis of osteoarthritis
J Martel-Pelletier, D Lajeunesse… - Arthritis and Allied …, 2005 - arthrolab.com
Osteoarthritis (OA) results from interaction among a number of complex biologic processes,
both degradative and reparative. There is a growing trend to view the joint as an entire …
both degradative and reparative. There is a growing trend to view the joint as an entire …
[HTML][HTML] Identifying effector molecules, cells, and cytokines of innate immunity in OA
MHJ Van den Bosch, P Van Lent… - Osteoarthritis and …, 2020 - Elsevier
Inflammatory changes are observed in affected joints of osteoarthritis (OA) patients and are
thought to be involved in the pathology that develops along OA progression. This narrative …
thought to be involved in the pathology that develops along OA progression. This narrative …
Proteomics of osteoarthritic chondrocytes and cartilage
Osteoarthritis (OA) is characterized by irreversible destruction of the articular cartilage. OA
affects more than 100 million individuals worldwide and has a major impact on patients' …
affects more than 100 million individuals worldwide and has a major impact on patients' …
[HTML][HTML] Subchondral bone proteomics in osteoarthritis: current status and perspectives
Osteoarthritis (OA) is the most common degenerative joint disorder. OA was conceived as a
“wear and tear” problem of articular cartilage, yet there is a lack of treatment options to delay …
“wear and tear” problem of articular cartilage, yet there is a lack of treatment options to delay …
Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis—structure, chaos and senescence
T Aigner, S Söder, PM Gebhard, A McAlinden… - Nature Clinical Practice …, 2007 - nature.com
The extracellular matrix of articular cartilage is the primary target of osteoarthritic cartilage
degradation. However, cartilage cells have a pivotal role during osteoarthritis, as they are …
degradation. However, cartilage cells have a pivotal role during osteoarthritis, as they are …