The extracellular matrix of articular cartilage is the primary target of osteoarthritic cartilage
degradation. However, cartilage cells have a pivotal role during osteoarthritis, as they are …

Purpose This manuscript will summarize the role of pro-inflammatory cytokines and tackle
newly discussed ones within the scope of OA pathogenesis as mentioned in the recent …

Osteoarthritis is first and foremost the ongoing destruction of the articular cartilages of joints.
Therefore, the extracellular matrix and the cells of the articular cartilages are the primary …

Although osteoarthritis (OA) is the most common musculoskeletal condition that causes
significant health and social problems worldwide, its exact etiology is still unclear. With an …

Osteoarthritis is a joint disease characterized by a poorly-defined inflammatory response
that does not encompass a massive immune cell infiltration yet contributes to cartilage …

Osteoarthritis is a common disease and is frequently encountered in the older population;
the incidence rises sharply with age. It is estimated that more than 360 million people suffer …

Osteoarthritis (OA) is a family of degenerative diseases affecting multiple joint tissues.
Despite the diverse etiology and pathogenesis of OA, increasing evidence suggests that …

Osteochondral junction is a functional unit comprising the articular cartilage, calcified
cartilage, and subchondral bone. Alteration in any component of this composite unit can …

Osteoarthritis (OA) is a long-term condition that causes joint pain and reduced movement.
Notably, the same pathways governing cell growth, death, and differentiation during the …

Osteoarthritis (OA) is a chronic disease affecting joints and further causing disabilities. This
disease affects around 240 million people worldwide. It is a multifactorial disease, and its …