The interplay between cellular stress and immune response can be variable and sometimes
contradictory. The mechanisms by which stress-activated pathways regulate the …

Inflammation represents the driving feature of many diseases, including atherosclerosis,
cancer, autoimmunity and infections. It is now established that metabolic processes shape a …

The liver X receptor (LXR) is a key transcriptional regulator of cholesterol, fatty acid, and
phospholipid metabolism. Dynamic remodeling of immunometabolic pathways, including …

The liver X receptors (LXRs), LXRα and LXRβ, are transcription factors with well-established
roles in the regulation of lipid metabolism and cholesterol homeostasis. In addition, LXRs …

Dyslipidemia, or altered blood lipid content, is a risk factor for developing cardiovascular
disease. Furthermore, several autoimmune diseases, including systemic lupus …

The liver X receptors (LXRs), LXRα and LXRβ, are nuclear receptors that regulate lipid
homeostasis. LXRs also regulate inflammatory responses in cultured macrophages …

Atherosclerosis can be considered as both a chronic inflammatory disease and a lipid
metabolism disorder. Innate immunity pathways have long been suspected to contribute to …

Human aging is associated with an increase in immune cell cholesterol levels, independent
of circulating cholesterol levels. The effects of such an increase in membrane cholesterol on …

High density lipoproteins (HDL) are heterogeneous particles composed by a vast array of
proteins and lipids, mostly recognized for their cardiovascular (CV) protective effects …

Liver X receptor (LXR) α expression is mainly localized to metabolic tissues, such as the
liver, whereas LXR β is ubiquitously expressed. LXR α is activated by oxysterols and plays …