Liver X receptors (LXRs) are nuclear receptors regulating lipid and cholesterol metabolism.
Recent data revealed a cross talk between LXR and Toll-like receptor signaling in …

Lipid metabolism has emerged as an important modulator of innate and adaptive immune
cell fate and function. The lipid‐activated transcription factors peroxisome proliferator …

Dendritic cells (DCs) respond to changes in their lipid environment by altering gene
expression and immunophenotype. Some of these alterations are mediated via the nuclear …

Liver X Receptors (LXR) control cholesterol metabolism and exert anti-inflammatory actions
but their contribution to human macrophage polarization remains unclear. The LXR pathway …

The nuclear receptors liver X receptor (LXR) LXRα and LXRβ are differentially expressed
ligand-activated transcription factors that induce genes controlling cholesterol homeostasis …

Inflammation and immune dysfunction have been increasingly recognized as crucial
mechanisms in atherogenesis. Modifications in cell lipid metabolism, plasma dyslipidaemia …

IL-5 stimulates production of T15/EO6 IgM antibodies that can block the uptake of oxidized
low density lipoprotein by macrophages, whereas a deficiency in macrophage IL-5 …

Cholesterol is essential for membrane synthesis; however, the mechanisms that link cellular
lipid metabolism to proliferation are incompletely understood. We demonstrate here that …

The liver X receptors (LXRs) are transcriptional regulators of lipid homeostasis that also
have potent anti-inflammatory effects. The molecular basis for their anti-inflammatory effects …

Objective—Liver X receptors (LXRs) modulate cholesterol and fatty acid homeostasis as
well as inflammation. This study aims to decipher the role of LXRs in the regulation of …