There is great interest in discovering targets for in vitro manipulation of autologous T cells
that enhance their cytotoxicity against tumor targets as a potent cancer immunotherapy. In a …

Objective—Liver X receptors (LXRs) are oxysterol-activated nuclear receptors regulating
reverse cholesterol transport, in part by modulating cholesterol efflux from macrophages to …

This review provides a summary of recent research on the role of high-density lipoprotein
(HDL)/apolipoprotein AI cholesterol efflux and immune cell function. Plasma concentrations …

CD30, a lymphoid activation marker, is shed into the cell environment after endoproteolytic
cleavage of its ectodomain. Soluble (s) CD30 is able to suppress the Th1-type immune …

Liver X receptor (LXR) agonists increase both total fecal sterol excretion and macrophage-
specific reverse cholesterol transport (RCT) in vivo. In this study, we assessed the effects of …

Background—The nuclear liver X receptor-α (LXR-α) has been implicated in the regulation
of intracellular cholesterol homeostasis, inflammatory response, and atherosclerosis …

Cholesterol is a member of the sterol family that plays essential roles in biological
processes, including cell membrane stability and myelin formation. Cholesterol can be …

An emerging area of investigation is the role of lipids as immunological antigens. CD1
glycoproteins comprise a family of molecules that are specialized for presenting lipids …

Objective—Liver X receptor (LXR) activators decrease atherosclerosis in mice. LXR
activators (1) directly upregulate genes involved in reverse cholesterol transport and (2) …

Liver X receptors (LXRs) exert key functions in lipid homeostasis and in control of
inflammation. In this study we have explored the impact of LXR activation on the …