Macrophages are key immune cells for the initiation and development of atherosclerotic
lesions. However, the macrophage regulatory nodes that determine how lesions progress in …

The oxysterol-activated nuclear receptor liver X receptor α (LXRα) has been implicated in
the control of both cholesterol and fatty acid metabolism. In this study, we have evaluated the …

The liver X receptors (LXRs) are nuclear receptors with established roles in the regulation of
lipid metabolism. We now show that LXR signaling not only regulates macrophage …

Reprogramming of metabolic pathways in monocytes and macrophages can induce a
proatherosclerotic inflammatory memory called trained innate immunity. Here, we have …

Lipid rafts are specialized plasma membrane microdomains, in which glycosphingolipids
and cholesterol are major structural components. In T lymphocytes, several signaling …

The nuclear receptor Liver X Receptor (LXR) is a ligand-activated transcription factor that
has been implicated in control of chronic inflammation by downregulating pro-inflammatory …

Rationale: Diverse B cell responses and functions may be involved in atherosclerosis.
Protective antibody responses, such as those against oxidized lipid epitopes, are thought to …

Changes in plasma lipoprotein profiles, particularly low levels of high‐density lipoprotein
(HDL) cholesterol, are associated with several inflammatory and immune diseases …

Blood monocytes are heterogeneous effector cells of the innate immune system. In
circulation these cells are constantly in contact with lipid-rich lipoproteins, yet this interaction …

The activation of liver X receptor (LXR) promotes cholesterol efflux and repression of
inflammatory genes with anti-atherogenic consequences. The mechanisms underlying the …