Liver X receptors (LXR) are oxysterol-activated nuclear receptors that play a central role in
reverse cholesterol transport through up-regulation of ATP-binding cassette transporters …

Rationale: Diverse B cell responses and functions may be involved in atherosclerosis.
Protective antibody responses, such as those against oxidized lipid epitopes, are thought to …

Liver X receptor (LXR) activation represents a mechanism to prevent macrophage foam cell
formation. Previously, we demonstrated that partial inhibition of oxidosqualene: lanosterol …

Liver X receptors (LXRs) are cholesterol-sensing nuclear receptors that are not only key
regulators of lipid metabolism and transport but also suppress inflammatory signaling in …

Background—Liver X receptors (LXRs) are ligand-activated transcription factors involved in
the control of lipid metabolism and inflammation. Synthetic LXR agonists have been shown …

Cholesterol is the obligate precursor to adrenal steroids but is cytotoxic at high
concentrations. Here, we show the role of the liver X receptors (LXRα and LXRβ) in …

Objective—The ability of high-density lipoprotein (HDL) particles to accept cholesterol from
peripheral cells, such as lipid-laden macrophages, and to transport cholesterol to the liver …

Objective: We sought to determine the liver X receptor (LXR) ligands present in human
macrophages after myelin phagocytosis and whether LXRs are activated in multiple …

Objective—We previously reported that a systemic liver X receptor (LXR) agonist promoted
macrophage reverse-cholesterol transport (mRCT) in vivo. Because LXR are expressed in …

Crosstalk exists in mammalian cells between cholesterol trafficking and innate immune
signaling. Apolipoprotein AI (apoA-I), a serum apolipoprotein that induces antiatherogenic …