Natural aging is accompanied by a dysregulation of the host immune response that has well-
known clinical consequences but poorly defined underlying causes. It has previously been …

Metabolic conditions such as obesity and associated comorbidities are increasing in
prevalence worldwide. In chronically inflamed pathologies, metabolic conditions are linked …

OBJECTIVE: Depletion of cholesterol by methyl-β-cyclodextrin (MCD) on peptide-loaded
antigen presenting cells (APCs) inhibits antigen presentation and T cell activation. However …

Compartmentalization and spatial control of biochemical reactions is the foundation of cell-
based life on earth. The lipid bilayer system employed by eukaryote cells not only keeps …

Despite the well-established role of liver X receptors (LXRs) in regulating cholesterol
homeostasis, their contribution to lipid homeostasis remains unclear. Here we show that …

The liver X receptors (LXRα and LXRβ) are members of the nuclear receptor family of
transcription factors that play essential roles in the transcriptional control of lipid metabolism …

Cholesterol, the most important sterol in mammals, helps maintain plasma membrane fluidity
and is a precursor of bile acids, oxysterols, and steroid hormones. Cholesterol in the body is …

Cells have evolved multiple mechanisms for maintaining cholesterol homeostasis, and,
among these, ATP-binding cassette protein A1 (ABCA1)-mediated cholesterol efflux is …

Atherosclerosis has been characterized as a chronic inflammatory response to cholesterol
deposition in arteries, but the mechanisms linking cholesterol accumulation in macrophage …

Dyslipidemia is a major cause of cardiovascular diseases which represent a leading cause
of death in humans. Diverse immune cells are known to be involved in the pathogenesis of …