[HTML][HTML] Immunologic aspects of dyslipidemia: a critical regulator of adaptive immunity and immune disorders
D Kim, H Chung, JE Lee, J Kim, J Hwang… - Journal of Lipid and …, 2021 - ncbi.nlm.nih.gov
Dyslipidemia is a major cause of cardiovascular diseases which represent a leading cause
of death in humans. Diverse immune cells are known to be involved in the pathogenesis of …
of death in humans. Diverse immune cells are known to be involved in the pathogenesis of …
Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses
Q Zeng, S Wang, M Li, S Wang, C Guo, X Ruan… - Cell Metabolism, 2023 - cell.com
Autoreactive B cell responses are essential for the development of systemic lupus
erythematosus (SLE). Fibroblastic reticular cells (FRCs) are known to construct lymphoid …
erythematosus (SLE). Fibroblastic reticular cells (FRCs) are known to construct lymphoid …
CD11c+ Dendritic Cells Maintain Antigen Processing, Presentation Capabilities, and CD4+ T-Cell Priming Efficacy Under Hypercholesterolemic Conditions …
RRS Packard, E Maganto-García, I Gotsman… - Circulation …, 2008 - Am Heart Assoc
Recent reports suggest dyslipidemia impairs dendritic cell (DC) function and adaptive
immunity. This study aimed to characterize the effect of hypercholesterolemia on antigen …
immunity. This study aimed to characterize the effect of hypercholesterolemia on antigen …
Inflammation triggers liver X receptor-dependent lipogenesis
SR Liebergall, J Angdisen, SH Chan… - … and cellular biology, 2020 - Taylor & Francis
Immune cell function can be modulated by changes in lipid metabolism. Our studies indicate
that cholesterol and fatty acid synthesis increases in macrophages between 12 and 18 h …
that cholesterol and fatty acid synthesis increases in macrophages between 12 and 18 h …
Apolipoprotein AI and HDL3 inhibit spreading of primary human monocytes through a mechanism that involves cholesterol depletion and regulation of CDC42
W Diederich, E Orso, W Drobnik, G Schmitz - Atherosclerosis, 2001 - Elsevier
The objective of the current study was to characterize the influence of high density
lipoproteins (HDL) on processes related to the vascular recruitment of human monocytes …
lipoproteins (HDL) on processes related to the vascular recruitment of human monocytes …
Reciprocal regulation of inflammation and lipid metabolism by liver X receptors
SB Joseph, A Castrillo, BA Laffitte, DJ Mangelsdorf… - Nature medicine, 2003 - nature.com
Macrophages have important roles in both lipid metabolism and inflammation and are
central to the pathogenesis of atherosclerosis. The liver X receptors (LXRs) are established …
central to the pathogenesis of atherosclerosis. The liver X receptors (LXRs) are established …
Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target
S Hummasti, BA Laffitte, MA Watson, C Galardi… - Journal of Lipid …, 2004 - ASBMB
The liver X receptors α and β (LXRα and LXRβ) have been shown to play important roles in
lipid homeostasis in liver and macrophages, however, their function in adipose tissue is not …
lipid homeostasis in liver and macrophages, however, their function in adipose tissue is not …
Lower Apo AI and Lower HDL-C Levels Are Associated With Higher Intermediate CD14++CD16+ Monocyte Counts That Predict Cardiovascular Events in Chronic …
KS Rogacev, AM Zawada, I Emrich… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Patients with chronic kidney disease (CKD) display impaired cholesterol efflux
capacity and elevated CD14++ CD16+ monocyte counts. In mice, dysfunctional cholesterol …
capacity and elevated CD14++ CD16+ monocyte counts. In mice, dysfunctional cholesterol …
Inflammation and skin cholesterol in LDLr−/−, apoA-I−/− mice: link between cholesterol homeostasis and self-tolerance?
M Zabalawi, M Bharadwaj, H Horton, M Cline… - Journal of lipid …, 2007 - ASBMB
Diet-fed low density lipoprotein receptor-deficient/apolipoprotein AI-deficient (LDLr−/−, apoA-
I−/−) mice accumulate a 10-fold greater mass of cholesterol in their skin despite a 1.5-to 2 …
I−/−) mice accumulate a 10-fold greater mass of cholesterol in their skin despite a 1.5-to 2 …
Low-density lipoprotein-reactive T cells regulate plasma cholesterol levels and development of atherosclerosis in humanized hypercholesterolemic mice
Background: Atherosclerotic cardiovascular disease is a chronic inflammatory process
initiated when cholesterol-carrying low-density lipoprotein (LDL) is retained in the arterial …
initiated when cholesterol-carrying low-density lipoprotein (LDL) is retained in the arterial …