Background Monocyte subpopulations distinguished by differential expression of chemokine
receptors CCR2 and CX3CR1 are difficult to track in vivo, partly due to lack of CCR2 …

Myeloid cells are mediators of central nervous system (CNS) damage and recovery in
neuroinflammatory and neurodegenerative disorders. Besides endogenous myelomonocytic …

Background The chemokine (CC motif) ligand 2 (CCL2) is a monocyte chemoattractant
protein that mediates macrophage recruitment and migration during peripheral and central …

The chemokine receptor CCR2 plays a vital role for the induction of autoimmunity in the
central nervous system. However, it remains unclear how the pathogenic response is …

Chemokines are a group of pro-inflammatory peptides that mediate leukocyte migration and
activation. Several members of the chemokine family have been shown to be synthesized by …

Monocyte recruitment to sites of inflammation is regulated by members of the chemokine
family of chemotactic cytokines. However, the mechanisms that govern the migration of …

Mononuclear phagocytes (monocytes, macrophages, and microglia) are considered central
to multiple sclerosis (MS) pathogenesis. Molecular cues that mediate mononuclear …

Chemokine receptor CCR2 mediates monocyte mobilization from the bone marrow (BM)
and subsequent migration into target tissues. The degree to which CCR2 is differentially …

Microglial cells in brain and spinal cord are characterized by high expression of the
chemokine receptor CX3CR1. Expression of the sole CX3CR1 ligand, the membrane …

Wallerian degeneration is one of the most elementary reactions of the nervous system after
transection of axons, leading to the recruitment of mononuclear cells from the systemic …