Clinically translatable large animal models have become indispensable for cardiovascular
research, clinically relevant proof of concept studies and for novel therapeutic interventions …

Cardiac damage is widely present in patients with metabolic diseases, but the exact
pathophysiological mechanisms involved remain unclear. The porcine heart is an ideal …

The heart has been the center of numerous transcriptomic studies in the past decade. Even
though our knowledge of the key organ in our cardiovascular system has significantly …

Background—Microarrays and RNA sequencing are widely used to profile transcriptome
remodeling during myocardial ischemia. However, the steady-state RNA analysis lacks in …

Cardiac diseases compose a fatal disease category worldwide. Over the past decade, high-
throughput transcriptome sequencing of bulk heart tissues has widened our understanding …

Background High throughput gene expression profiling assays of peripheral blood are
widely used in biomedicine, as well as in animal genetics and physiology research …

The development of the cardiac conduction system (CCS) is essential for correct heart
function. However, critical details on the cell types populating the CCS in the mammalian …

Background: Despite the critical role of the cardiovascular system, our understanding of its
cellular and transcriptional diversity remains limited. We therefore sought to characterize the …

Rationale: Accurate and comprehensive de novo transcriptome profiling in heart is a central
issue to better understand cardiac physiology and diseases. Although significant progress …

Although diabetes mellitus (DM) causes cardiomyopathy and exacerbates heart failure, the
underlying molecular mechanisms for diabetic cardiomyopathy/heart failure are poorly …