Highlights• Oxygen fixes DNA damage by free radicals and cells are 2–3 times more
radioresistant to sparsely ionising radiation when irradiated in the absence of oxygen.• OER …

Regions of reduced oxygenation (hypoxia) are a characteristic feature of virtually all animal
and human solid tumours. Numerous preclinical studies, both in vitro and in vivo, have …

Tumour hypoxia is a major constraint for radiotherapy and many types of chemotherapy. A
variety of different pathogenetic mechanisms contribute to the development of hypoxia in …

Hypoxia has for many years been acknowledged to be a characteristic physiological
abnormality in solid tumours. It arises primarily because the tumour microcirculation that …

For more than 100 years, it has been suspected that oxygen levels can influence the
radiosensitivity of cells (1). Further basic investigations on the importance of hypoxia for …

Hypoxia is a common feature of malignant tumors. There is an interactive connection
between hypoxia and chemoresistance, radioresistance, invasiveness, and angiogenesis …

Cells undergo a variety of biological responses when placed in hypoxic conditions,
including activation of signalling pathways that regulate proliferation, angiogenesis and …

Since the initial observations made at the beginning of the last century, it has been
established that solid tumors contain regions of low oxygenation (hypoxia). Tumor cells can …

Abstract Learning Objectives After completing this course, the reader will be able to: Explain
the effect of hypoxia on resistance to treatment. Describe the causes of tumor hypoxia …

Tumor hypoxia is a common feature of the microenvironment in solid tumors, primarily due to
an inadequate, and heterogeneous vascular network. It is associated with resistance to …