Excess adiposity can induce adverse sequelae in multiple cell types and organ systems.
The transition from the lean to the obese state is characterized by fundamental cellular …

A healthy adipose tissue (AT) is indispensable to human wellbeing. Among other roles, it
contributes to energy homeostasis and provides insulation for internal organs. Adipocytes …

Adipocytes secrete a number of bioactive adipokines that activate a variety of cell signaling
pathways in central and peripheral tissues. Obesity is associated with the altered production …

Fat tissue is a storage depot for energy and a source of circulating signaling molecules. It
plays an important role in the catabolic uremic milieu, and has been linked to systemic …

An activated inflammatory response is a common feature of end-stage renal disease (ESRD)
patients and predicts outcome. Although various factors related to the dialysis procedure …

Despite considerable efforts to better characterize the pathophysiology of obesity-related
metabolic disease, there are still a lack of efficient therapeutic strategies. New strategies …

The metabolic effects of obesity have made this highly prevalent disease one of the most
common risk factors for diabetes, hypertension, and atherosclerosis, the leading causes of …

Cardiovascular disease remains a major cause of morbidity and mortality in end-stage renal
disease patients. As traditional risk factors cannot alone explain the unacceptable high …

Adipose tissue as a source of inflammatory cytokines in health and disease: Focus on end-
stage renal disease. Adipose tissue is a necessary survival characteristic of species that do …

The rapid growth in obesity worldwide contributes to an increase in metabolic syndrome and
obesity-related kidney disease with an enhanced increased risk for chronic kidney disease …