Neurons spurn hydrogen-rich fatty acids for energizing oxidative ATP synthesis, contrary to
other cells. This feature has been mainly attributed to a lower yield of ATP per reduced …

It is puzzling that hydrogen-rich fatty acids are used only poorly as fuel in the brain. The long-
standing belief that a slow passage of fatty acids across the blood–brain barrier might be the …

The brain uses long-chain fatty acids (LCFAs) to a negligible extent as fuel for the
mitochondrial energy generation, in contrast to other tissues that also demand high energy …

Metabolic coordination between neurons and astrocytes is critical for the health of the brain.
However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural …

The metabolic state of the brain can greatly impact neurologic function. Evidence of this
includes the therapeutic benefit of a ketogenic diet in neurologic diseases, including …

Fatty acids are of paramount importance to all cells, since they provide energy, function as
signaling molecules, and sustain structural integrity of cellular membranes. In the nervous …

The human brain is nearly 60 percent fat. We've learned in recent years that fatty acids are
among the most crucial molecules that determine your brain's integrity and ability to perform …

Brain fatty acid (FA) metabolism deserves a close attention not only for its energetic aspects
but also because FAs and their metabolites/derivatives are able to influence many neural …

In this review, we analyze the current hypotheses regarding energy metabolism in the
neurons and astroglia. Recently, it was shown that up to 20% of the total brain's energy is …

It is increasingly understood that in the aging brain, especially in the case of patients
suffering from neurodegenerative diseases, some fatty acids at pathologically high …