Macrophages represent an important cellular target of HIV-1. Interestingly, they are also
believed to play a potential role counteracting its infection. However, HIV-1 is known to …

Macrophage immune functions such as antibody-mediated phagocytosis are strongly
impaired in individuals affected by HIV-1. Nevertheless, infected macrophages are still able …

Active targeting nano-delivery is a promising approach to enhance therapeutic efficacy and
specificity to the target cells. Liposomes (LPs) have been widely studied for the active …

As the number of individuals infected with human immunodeficiency virus (HIV) is growing
dramatically throughout the world, it is important to develop strategies to improve the …

Functionalization of experimental HIV-1 virus-like particle vaccines with heterologous T
helper epitopes (T helper VLPs) can modulate the humoral immune response via …

Aim: Based on the ability of apoptosis to induce immunological tolerance, liposomes were
generated mimicking apoptotic cells, and they arrest autoimmunity in Type 1 diabetes. Our …

Nanomedicine holds immense potential for therapeutic manipulation of phagocytic immune
cells. However, in vitro studies often fail to accurately translate to the complex in vivo …

Current antiretroviral drugs used to prevent or treat human immunodeficiency virus type 1
(HIV-1) infection are not able to eliminate the virus within tissues or cells where HIV …

Autoimmune diseases (AIDs) are caused by the loss of self-tolerance and destruction of
tissues by the host's immune system. Several antigen-specific immunotherapies, focused on …

Aim: To develop lipid nano-antiretrovirals (LNAs) for the treatment of HIV-infected
macrophages. Materials & methods: LNAs were prepared with docosahexaenoic acid to …