Botulinum toxin type A (BoNT/A) produced by Clostridium botulinum inhibits Ca2+-
dependent acetylcholine (ACh) release (neuroexocytosis) at peripheral neuromuscular …

The molecular mechanisms of depolarization-induced calcium-dependent acetylcholine
(ACh) release and its inhibition by botulinum neurotoxin type A (BoTx) are not clear. We …

Inhibition of Rho activity by Clostridium botulinum C3 transferase (C3bot) versatily changes
functional properties of neural cells. Using cultivated mouse astrocytes, we show here that …

ABSTRACT Small GTPases of the Rho family play versatile roles in the formation and
development of axons and dendrites, effects often studied by the Rho‐inactivating C3 …

RhoA,-B, and-C are ADP-ribosylated by Clostridium botulinum exoenzyme C3 to induce
redistribution of the actin filaments in intact cells, a finding that has led to the notion that the …

Botulinum neurotoxin A (BoNT A) is a substrate of the Src family of tyrosine kinases. Here,
we report that the BoNT A light chain (LC) is phosphorylated in the tyrosine‐71 located at N …

Clostridial neurotoxins' metalloprotease domain selectively cleaves proteins implicated in
the process of synaptic vesicle fusion with the plasma membrane and, accordingly, blocks …

GTP-BINDrNG proteins can be divided into three categories. The first is those involved in
protein synthesis such as elongation factors in ribosomes. The second is a group of …

Botulinum neurotoxins produced by various Clostridium sp are the most potent acute lethal
toxins known, and yet they have found increasing use in the clinical treatment of diseases or …

Clostridium botulinum type toxin A (BoTx) blocks stimulus-induced acetylcholine (ACh)
release from presynaptic nerve terminals at peripheral neuromuscular junctions. However …