Anion gap reference intervals show instrument dependence and weak correlation with albumin levels

B Pratumvinit, L Lam, N Kongruttanachok… - Clinica Chimica …, 2020 - Elsevier
Background Anion gap (AG) aids the differential diagnosis of acid-base disorders. Its value
has decreased, because of new analytical methods. Our goal was to compare AG reference …

Interpreting anion gap values in adult and pediatric patients: examining the reference interval

N Ayala-Lopez, R Harb - The Journal of Applied Laboratory …, 2020 - academic.oup.com
Background The anion gap is primarily used in the diagnosis of acid-base disorders. We
conducted a study to determine the anion gap reference interval in our patient population …

Influence of hypoalbuminemia or hyperalbuminemia on the serum anion gap

M Feldman, N Soni, B Dickson - Journal of Laboratory and Clinical …, 2005 - Elsevier
Background: Conflicting data exist as to what extent hypoalbuminemia reduces the anion
gap; estimates range from 1.5 to 2.5 mM per g/dL decrease in serum albumin. Methods: We …

Wide variation in serum anion gap measurements by chemistry analyzers

WD Paulson, WL Roberts, AA Lurie… - American journal of …, 1998 - academic.oup.com
The traditional anion gap [AG= Na–Cl–(total CO2)] mean value of 12 mEq/L was established
during the 1970s with analyzer methods that are no longer used widely. No studies have …

Value of the anion gap in clinical diagnosis and laboratory evaluation.

PH Lolekha, S Lolekha - Clinical chemistry, 1983 - academic.oup.com
We report the incidence of normal (50.4%), increased (46.7%), and decreased (2.9%) anion
gap among hospitalized patients in a retrospective study. The mean and range of increased …

Update on value of the anion gap in clinical diagnosis and laboratory evaluation

PH Lolekha, S Vanavanan, S Lolekha - Clinica chimica acta, 2001 - Elsevier
Anion gap (AG) is a calculated value commonly used in clinical practice. It approximates the
difference between the concentration of unmeasured anions (UA) and unmeasured cations …

The serum anion gap in the evaluation of acid-base disorders: what are its limitations and can its effectiveness be improved?

JA Kraut, GT Nagami - Clinical Journal of the American Society of …, 2013 - journals.lww.com
The serum anion gap has been utilized to identify errors in the measurement of electrolytes,
to detect paraproteins, and, most relevant to the nephrologist, to evaluate patients with …

The fall of the serum anion gap

SD Winter, JR Pearson, PA Gabow… - Archives of internal …, 1990 - jamanetwork.com
• Using modern electrode technology (Beckman ASTRA analyzer), we evaluated the
reference range for the anion gap (calculated as sodium minus chloride minus bicarbonate …

Gaps in the anion gap

MM Salem, SK Mujais - Archives of internal medicine, 1992 - jamanetwork.com
Objective.—To review limitations of the use of serum anion gap in clinical practice. Data
Sources.—Original reports and reviews. Study Selection.—Sources containing the most …

Serum anion gap: its uses and limitations in clinical medicine

JA Kraut, NE Madias - Clinical journal of the American Society of …, 2007 - journals.lww.com
The serum anion gap, calculated from the electrolytes measured in the chemical laboratory,
is defined as the sum of serum chloride and bicarbonate concentrations subtracted from the …