Insulin secretion in β-pancreatic cells due to glucose stimulation requires the coordinated
alteration of cellular ion concentrations and a substantial membrane depolarization to …

TRPM4 is a calcium-activated non-selective cation channel that is widely expressed and
proposed to be involved in cell depolarization. In excitable cells, TRPM4 may regulate …

TRPM4 is a Ca2+-activated non-selective cation (CAN) channel that functions in cell
depolarization, which is important for Ca2+ influx and insulin secretion in pancreatic β-cells …

Insulin secretion from pancreatic β-cells is the primary mechanism by which the body lowers
blood glucose concentrations. Glucose is the principal stimulator of insulin secretion, and …

Glucose homeostasis is critically dependent on insulin release from pancreatic β-cells,
which is strictly regulated by glucose-induced oscillations in membrane potential (Vm) and …

OBJECTIVE TRPM2 is a Ca2+-permeable nonselective cation channel activated by
adenosine dinucleotides. We previously demonstrated that TRPM2 is activated by …

Abstract TRPM2 is a Ca 2+-permeable non-selective cation channel that can be activated by
adenosine dinucleotides, hydrogen peroxide, or intracellular Ca 2+. The protein is …

Blood glucose concentration is tightly regulated by the rate of insulin secretion and
clearance, a process partially controlled by sensory neurons serving as metabolic sensors in …

There is now overwhelming evidence that TRP channels might play a significant role in the
regulation of insulin release from pancreatic β cells, which is until now insufficiently …

We recently proposed that the transient receptor potential melastatin 5 (TRPM5) cation
channel contributes to glucose-induced electrical activity of the β cell and positively …