Since the tumor necrosis factor alpha (TNF-α) gene was found to be located in the central
major histocompatibility complex (MHC) there has been much speculation concerning a …

The tumor necrosis factor (TNF) alpha gene lies within the class III region of the major
histocompatibility complex (MHC), telomeric to the class II and centromeric to the class I …

Tumor necrosis factor alpha (TNF alpha) is a central mediator of the immunological
response and the location of the gene within the major histocompatibility complex (MHC) …

Tumor necrosis factor-alpha (TNF-α) is a potent immunomediator and proinflammatory
cytokine that has been implicated in the pathogenesis of a large number of human diseases …

Tumor necrosis factor α (TNFα) is a potent inflammatory cytokine. In human, the TNFα gene
is located within the highly polymorphic major histocompatibility complex (MHC) region on …

We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc)
within a 12-kilobase region of the human major histocompatibility complex (MHC) that …

Abstract A biallelic G (TNF1 allele) to A (TNF2 allele) polymorphism 308 nucleotides
upstream from the transcription initiation site in the tumor necrosis factor (TNF) promoter is …

We have identified three new human tumor necrosis factor‐α (TNF‐α) promoter
polymorphisms with single nucleotide (nt) substitutions at‐862,‐856, and‐574 nt relative to …

As more and more polymorphisms are discovered in the genes encoding cytokines, a crucial
question is whether this polymorphism has any functional effect. One of the most widely …

Tumour necrosis factor-alpha (TNF-alpha) is a potent immunomediator and proinflammatory
cytokine that has been implicated in the pathogenesis of a large number of human diseases …