DDX3X and DDX3Y are redundant in protein synthesis
DDX3 is a DEAD-box RNA helicase that regulates translation and is encoded by the X-and
Y-linked paralogs DDX3X and DDX3Y. While DDX3X is ubiquitously expressed in human …
Y-linked paralogs DDX3X and DDX3Y. While DDX3X is ubiquitously expressed in human …
[HTML][HTML] The human DEAD-box helicase DDX3X as a regulator of mRNA translation
CS Ryan, M Schröder - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
The human DEAD-box protein DDX3X is an RNA remodelling enzyme that has been
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …
implicated in various aspects of RNA metabolism. In addition, like many DEAD-box proteins …
DDX3 regulates cell growth through translational control of cyclin E1
MC Lai, WC Chang, SY Shieh… - Molecular and cellular …, 2010 - Taylor & Francis
DDX3 belongs to the DEAD box family of RNA helicases, but the details of its biological
function remain largely unclear. Here we show that knockdown of DDX3 expression …
function remain largely unclear. Here we show that knockdown of DDX3 expression …
The current understanding of Ded1p/DDX3 homologs from yeast to human
WY Tarn, TH Chang - RNA biology, 2009 - Taylor & Francis
DExD/H-box RNA helicases are involved in almost all steps of the eukaryotic mRNA
biogenesis. The DEAD-box protein Ded1p/DDX3 is conserved from yeast to human. Various …
biogenesis. The DEAD-box protein Ded1p/DDX3 is conserved from yeast to human. Various …
The DDX3 subfamily of the DEAD box helicases: divergent roles as unveiled by studying different organisms and in vitro assays
A Rosner, B Rinkevich - Current medicinal chemistry, 2007 - ingentaconnect.com
DDX3 (or Ded1p), the highly conserved subfamily of the DEAD-box RNA helicase family (40
members in humans), plays important roles in RNA metabolism. DDX3X and DDX3Y, the …
members in humans), plays important roles in RNA metabolism. DDX3X and DDX3Y, the …
DDX3 depletion represses translation of mRNAs with complex 5′ UTRs
L Calviello, S Venkataramanan… - Nucleic acids …, 2021 - academic.oup.com
DDX3 is an RNA chaperone of the DEAD-box family that regulates translation. Ded1, the
yeast ortholog of DDX3, is a global regulator of translation, whereas DDX3 is thought to …
yeast ortholog of DDX3, is a global regulator of translation, whereas DDX3 is thought to …
[HTML][HTML] Rare de novo missense variants in RNA helicase DDX6 cause intellectual disability and dysmorphic features and lead to P-body defects and RNA …
The human RNA helicase DDX6 is an essential component of membrane-less organelles
called processing bodies (PBs). PBs are involved in mRNA metabolic processes including …
called processing bodies (PBs). PBs are involved in mRNA metabolic processes including …
[HTML][HTML] DDX3X regulates cell survival and cell cycle during mouse early embryonic development
Q Li, P Zhang, C Zhang, Y Wang, R Wan… - Journal of biomedical …, 2014 - ncbi.nlm.nih.gov
DDX3X is a highly conserved DEAD-box RNA helicase that participates in RNA
transcription, RNA splicing, and mRNA transport, translation, and nucleo-cytoplasmic …
transcription, RNA splicing, and mRNA transport, translation, and nucleo-cytoplasmic …
Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model
Mutations in the RNA helicase, DDX3X, are a leading cause of Intellectual Disability and
present as DDX3X syndrome, a neurodevelopmental disorder associated with cortical …
present as DDX3X syndrome, a neurodevelopmental disorder associated with cortical …
Human DDX3 functions in translation and interacts with the translation initiation factor eIF3
CS Lee, AP Dias, M Jedrychowski, AH Patel… - Nucleic acids …, 2008 - academic.oup.com
The conserved RNA helicase DDX3 is of major medical importance due to its involvement in
numerous cancers, human hepatitis C virus (HCV) and HIV. Although DDX3 has been …
numerous cancers, human hepatitis C virus (HCV) and HIV. Although DDX3 has been …