Metastasis accounts for 90% of cancer-related deaths among the patients. The
transformation of epithelial cells into mesenchymal cells with molecular alterations can occur …

Inhibition of Wnt/β-catenin pathway is an attractive method for therapy of various tumors
including breast, colorectal, and cervical cancer, etc. However, little is known about the role …

Cancer is one of the greatest public health challenges. According to the World Health
Organization (WHO), 9.6 million cancer deaths have been reported in 2018. The most …

The cell signaling cascades provoked by Wnt proteins (the Wnt signaling pathways), which
are well conserved through evolution, play crucial roles to maintain homeostasis of a variety …

The Wnt/β-catenin signaling pathway plays a crucial role in the development, tissue
homeostasis, angiogenesis, and carcinogenesis of cancer. Mutations and excessive …

Precise regulation of signal transduction pathways is crucial for normal animal development
and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated …

The Wnt/β-catenin signaling pathway, including canonical or noncanonical pathway, is a
highly conserved pathway which can regulate cell proliferation, migration, differentiation …

WNT/β-catenin signaling orchestrates various physiological processes, including embryonic
development, growth, tissue homeostasis, and regeneration. Abnormal WNT/β-catenin …

Introduction: The Wnt signaling pathway plays a major role in cancer development and
progression. As a novel anticancer drug can be developed using inhibitors of this pathway …

Our previous studies indicate that abnormal expression of several Wnt signaling molecules
including Axin, Dvl and β‐catenin are involved in proliferation, invasion and metastasis of …