Necroptosis is an inflammatory form of programmed cell death that has been implicated in
various human diseases. Compound 2 is a more potent analogue of the published …

Necroptosis contributes to the pathophysiology of several inflammatory, infectious and
degenerative disorders. TNF-induced necroptosis involves activation of the receptor …

For a long time, it was believed that apoptosis and necrosis were the main pathways for cell
death, but a growing body of research has shown that there are other pathways. Among …

Necroptosis is a programmed cell death pathway that has been shown to be of central
pathophysiological relevance in multiple disorders (hepatitis, brain and cardiac ischemia …

In the last few years, necroptosis, a recently described type of cell death, has been reported
to play an important role in the development of various brain pathologies. Necroptosis is a …

Cell death is a crucial event underlying cardiac ischemic injury, pathological remodeling,
and heart failure. Unlike apoptosis, necrosis had long been regarded as a passive and …

Necroptosis is a form of caspase-independent programmed cell death that arises from
disruption of cell membranes by the mixed lineage kinase domain-like (MLKL) …

Over the past decades, promising therapies targeting different signaling pathways have
emerged. Among these pathways, apoptosis has been well investigated and targeted to …

Regulated necrosis, also termed necroptosis, is another programmed cell death depending
on a unique molecular pathway that does not overlap with apoptosis. Tumor necrosis factor …

Cell death research was revitalized by the understanding that necrosis can occur in a highly
regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein …