In the early 2000s, receptor-interacting serine/threonine protein kinase 1 (RIPK1), a
molecule already recognized as an important regulator of cell survival, inflammation and …

Cell death research was revitalized by the understanding that necrosis can occur in a highly
regulated and genetically controlled manner. Although RIPK1 (receptor-interacting protein …

Within the field of medical science, there is a great deal of interest in investigating cell death
pathways in the hopes of discovering new drugs. Over the past two decades …

The family of death receptors plays a critical role in regulating cell number and eliminating
harmful or virally infected cells. Agonistic stimulation of death receptors is known to lead two …

Regulated cell death is a physiological process that controls organismal homeostasis.
Deregulation of cell death can lead to the development of a number of human diseases and …

Necroptosis is a form of programmed, caspase-independent cell death that is involved in
various pathologic disorders such as ischemia/reperfusion injury, acute kidney injury and …

Necroptosis, initially identified as a backup cell death program when apoptosis is hindered,
is a prominent feature in the etiology and progression of many human diseases, such as …

Necroptosis | New England Journal of Medicine Skip to main content The New England Journal
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Background Breast cancer remains a great threat to females worldwide. As a recently
defined programmed cell death pathway that associates with immune activation …

Necroptosis, a programmed cell death mechanism distinct from apoptosis, has garnered
attention for its role in various pathological conditions. While initially recognized for its …