Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic
stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune …

The hematopoietic system has the remarkable ability to provide a lifelong supply of mature
cells that make up the entire blood and immune system. However, similar to other adult stem …

Hematopoietic stem cells (HSCs) ensure a balanced production of all blood cells throughout
life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas …

Aging leads to functional decline of the hematopoietic system, manifested by an increased
incidence of hematological disease in the elderly. Deterioration of hematopoietic integrity …

Hematopoietic stem cells (HSC) sustain blood production over the entire life-span of an
organism. It is of extreme importance that these cells maintain self-renewal and …

Hematopoietic stem cell (HSC) aging, which is accompanied by reduced self-renewal ability,
impaired homing, myeloid-biased differentiation, and other defects in hematopoietic …

Hematopoietic stem cells (HSC) continuously replenish the blood and immune systems.
Their activity must be sustained throughout life to support optimal immune responses. It has …

Hematopoietic stem cells (HSCs) sustain the lifelong production of all blood cell lineages.
The functioning of aged HSCs is impaired, including a declined repopulation capacity and …

Hematopoietic stem cell (HSC) aging was originally thought to be essentially an HSC-
autonomous process, which is the focus of another review in the same issue of …

Highlights•HSCs accumulate functional and molecular defects with aging.•HSC aging
includes acquisition of somatic mutations leading to CH.•Both HSC-intrinsic and HSC …