In-depth knowledge of cancer molecular and cellular mechanisms have revealed a strong
regulation of cancer development and progression by the inflammation which orchestrates …

Interleukins and associated cytokines serve as the means of communication for innate and
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …

The interleukin‐1 (IL‐1) family consists of two major agonistic proteins, IL‐1α and IL‐1β,
which are pleiotropic and affect mainly inflammation, immunity, and hemopoiesis. The IL‐1 …

Inflammatory responses play pivotal roles in cancer development, including tumor initiation,
promotion, progression, and metastasis. Cytokines are now recognized as important …

IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-
inflammatory activity. Beyond its biological role as a regulator of the innate immune …

Chronic inflammation has been recognized as a canonical cancer hallmark. It is
orchestrated by cytokines, which are master regulators of the tumor microenvironment (TME) …

Inflammation is an important component of the tumor microenvironment. IL‐1 is an
inflammatory cytokine which plays a key role in carcinogenesis and tumor progression. IL‐1 …

Simple Summary Interleukin-1 cytokines are key proinflammatory cytokines which have
been implicated with differing pro-and antitumorigenic properties. Recent years have …

Over the past years, advances in cancer immunotherapy have resulted in innovative and
novel approaches in molecular cancer diagnostics and cancer therapeutic procedures …

Summary Interleukin-1 (IL-1) is a key orchestrator of inflammation and plays an important
role in tumor progression. Based on preclinical models and human genetic associations, we …