Adenosine A2A receptor antagonists have been proposed as an effective therapy in the
treatment of Parkinson's disease. To explore the possibility that dopamine denervation may …

Agonists bind with higher affinity to G protein-coupled heptahelical receptors than to
uncoupled receptors. Recombinant A1 and A3 adenosine receptors couple well to Gi/o, but …

Four adenosine receptors have been cloned from many mammalian and some non-
mammalian species. In each case the translated part of the receptor is encoded by two …

The A 2a adenosine receptor is a member of the G-protein coupled receptor family, and its
activation stimulates cyclic AMP production. To determine the residues which are involved in …

This brief review presents a personal perspective on the historical development of the
current knowledge about the biologically important concept of functional antagonism …

2‐p‐(2‐carboxyethylphenethylamino‐5′‐ethylcarboxamidoadenosine)(CGS 21680) is
considered the reference compound to study adenosine A2A receptors. However, CGS …

The extensive amino acid sequence conservation among G protein‐coupled receptors has
been exploited to clone new members of this large family by homology screening or by PCR …

[3H] NECA (1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-beta-D-ribofuronamide) is known to
bind to both the A1 and A2 subtypes of adenosine receptor in rat striatal membranes. In …

* Address correspondence to: PJM van Galen, NIH/NIDDK, Building 8A, Room B1A-17,
Bethesda, MD 20892; telephone 301-496-9024; fax 301-402-0008. Medicinal Research …

Adenosine A2A receptors are highly enriched in the basal ganglia system. They are
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …