Recent breakthroughs in crystallographic studies of G protein-coupled receptors (GPCRs),
together with continuous progress in molecular modeling methods, have opened new …

Structure-based design methods commonly used in medicinal chemistry rely on a three-
dimensional representation of the receptor. However, few crystal structures are solved in …

Dopamine (DA) receptors, a class of G-protein coupled receptors (GPCRs), have been
targeted for drug development for the treatment of neurological, psychiatric and ocular …

Rational drug design for G protein-coupled receptors (GPCRs) is limited by the small
number of available atomic resolution structures. We assessed the use of homology …

Homology model structures of the dopamine D2 receptor (D2R) were generated starting
from the active and inactive states of\upbeta β 2-adrenergic crystal structure templates. To …

G protein–coupled receptors (GPCRs) are intensely studied as drug targets and for their role
in signaling. With the determination of the first crystal structures, interest in structure-based …

Functionally selective ligands stabilize conformations of G protein-coupled receptors
(GPCRs) that induce a preference for signaling via a subset of the intracellular pathways …

Predicting the three‐dimensional structure of ligand–receptor complexes involving G protein‐
coupled receptors (GPCRs) is still a challenging task in rational drug design. To evaluate the …

In order to apply structure-based drug design techniques to G protein-coupled receptor
complexes, it is essential to model their 3D structure and to identify regions that are suitable …

A combined modeling approach was used to identify structural factors that underlie the
structure–activity relationships (SARs) of full dopamine D2 receptor agonists and structurally …