The plasticity of endothelin ET B receptor activity and the influence of pro-inflammatory
cytokines was examined in cerebral artery. In fresh rat basilar artery, the selective ET B …

Previously, we have demonstrated that mRNA expression of endothelin-1 (ET-1), a potent
vasoconstrictor, is induced in astrocytes and endothelial cells after ischemic conditions …

Background and Purpose—Substantial evidence now implicates endothelin (ET) in the
pathophysiology of cerebrovascular disorders such as the delayed vasospasm associated …

Excessive release of glutamate, from glial cells as well as neurons, is thought to be a major
cause of neuronal death in ischemia. To investigate glutamate release from glial cells, we …

Anxiety disorders contribute to the pathophysiology of psychiatric diseases, including major
depression, substance abuse, and schizophrenia. The hippocampus is important for anxiety …

WE reported here the first evidence that endothelin (ET)-1 and ET-3 produced an increase in
intracellular Ca 2+ concentrations ([Ca 2+] 1), consisting of a transient and a sustained …

To evaluate the expression of components of the endothelin (ET) system in single Purkinje
neurons and Bergmann glial cells in situ, patch-clamp recording was combined with a …

We investigated the effect of small cortical ischemic lesions, produced by intracerebral
injection of the vasoconstrictor endothelin-1, on neurogenesis in the adult mouse …

1 Endothelin (ET) has been implicated in cerebrovasospasm for example, following
subarachnoid haemorrhage, and blocking the interaction of ET with its receptors on cerebral …

Recently, it has been shown that brain topical superfusion of endothelin 1 (ET-1) at
concentrations around 100 nM induces repetitive cortical spreading depressions (CSD) in …