Endothelin-1 (ET-1) is the most potent vasoconstrictor agent known. ET-1 is elevated in the
cerebrospinal fluid following hemorrhage and brain injury and can compromise cerebral …

The role of functional endothelin-B (ETB)-receptors on neuronal survival upon hypoxia–
ischemia (HI) has been investigated in 14-day-old ETB-receptor-deficient spotting lethal …

Abstract Endothelin (ET)-1 and its receptors (ETA and ETB receptor) are present in the
central nervous system. ET exerts biological effects on gliogenesis and glial cell functions. In …

Effect of Endothelin-1 on the Excitability of Rat Cortical and Hippocampal Slices In Vitro Page
1 PHYSIOLOGICAL RESEARCH • ISSN 0862-8408(print) • ISSN 1802-9973(online) © 2012 …

The effects of endothelin 1 (ET-1; 300 pmol/rat intracarotid) on somatosensory evoked
potential were investigated in rats. ET-1 led to an amplitude reduction, peak latency …

Objectives: The syntheses of endothelin receptors A and B were previously shown to be
upregulated in rat dorsal hippocampus after traumatic brain injury. Here we characterize …

Endothelin 1 (ET-1) exerts normally a powerful vasoconstrictor role in the control of the brain
microcirculation. In altered states, such as following traumatic brain injury (TBI), it may …

Abstract Endothelin‐1 (ET‐1), an autocrine hormone synthesized by astrocytes, and
endothelin‐3 (ET‐3), a highly homologous peptide produced by neurons, have both been …

In addition to their potent vasoconstriction effects, endothelins (ETs) show multiple actions in
various tissues including the brain. The brain contains high levels of ETs, and their …

The kinetic properties of endothelin‐1 (ET‐1) binding sites and the production of inositol
phosphates (IPs; IP1, IP2, IP3), cyclic AMP, thromboxane B2, and prostaglandin F2α …