ETA and ETB Specific Ligands Synergistically Antagonize Endothelin‐1 Binding to an Atypical Endothelin Receptor in Primary Rat Astrocytes

N Jensen, M Hasselblatt, AL Sirén… - Journal of …, 1998 - Wiley Online Library
Using a whole‐cell binding procedure with long incubations at low temperature and
subsequent acid stripping, we have characterized an atypical endothelin (ET) receptor in …

Characterisation of Endothelin-1-Induced Intrastriatal Lesions Within the Juvenile and Adult Rat Brain Using MRI and 31P MRS

R Saggu - Translational stroke research, 2013 - Springer
Improved non-invasive magnetic resonance (MR) characterisation of in vivo models of focal
ischaemic insults such as transient ischaemic attack (TIA) and perinatal arterial ischaemic …

Both ETA and ETB receptors are involved in mitogen‐activated protein kinase activation and DNA synthesis of astrocytes: study using ETB receptor‐deficient rats …

Y Sasaki, S Hori, K Oda, T Okada… - European Journal of …, 1998 - Wiley Online Library
Endothelin (ET) is known to be a potent mitogen in astrocytes. However, the contribution and
signalling pathway of ETA and/or ETB receptor to the proliferation of astrocytes remain …

Endothelin enhances adenosine and isoprenaline elevated cyclic AMP levels in rat cerebellar slices

F Hernández, RE Catalán, AM Martinez - Peptides, 1999 - Elsevier
In this study, we present evidence showing that endothelin (ET) potentiates the responses to
adenosine, to 5′-N-ethylcarboxamidoad, a nonhydrolyzable adenosine agonist, and to …

Involvement of glial endothelin/nitric oxide in delayed neuronal death of rat hippocampus after transient forebrain ischemia

K Yamashita, Y Kataoka, Y Sakurai-Yamashita… - Cellular and molecular …, 2000 - Springer
We examined time-and cell-type-dependent changes in endothelin (ET)-1-like
immunoreactivity, ET receptors binding and nitric oxide (NO) synthase (NOS) activity in CA1 …

[PDF][PDF] Experimental SAH alters endothelin receptor phenotype in rat cerebral arteries

J Hansen-Schwartz, NL Hoel, M Zhou… - … in Research and …, 2004 - ndl.ethernet.edu.et
Organ culture of rat cerebral arteries is associated with alteration in the vascular endothelin
(ET) receptor population. We investigated if such changes also occur in cerebral arteries in a …

Endothelin-1 stimulates the release of preloaded [3H] D-aspartate from cultured cerebellar granule cells

WW Lin, CY Lee, DM Chuang - Biochemical and biophysical research …, 1990 - Elsevier
We have recently reported that endothelin-1 (ET) induces phosphoinositide hydrolysis in
primary cultures of rat cerebellar granule cells. Here we found that ET in a dose-dependent …

Changes in the cerebrovascular effects of endothelin-1 and nicardipine after experimental subarachnoid hemorrhage

JA Alabadí, JB Salom, G Torregrosa, FJ Miranda… - …, 1993 - journals.lww.com
Abstract THE ROLE OF endothelium-related factors in the pathogenesis of cerebral
vasospasm after subarachnoid hemorrhage (SAH) has gained interest since the discovery of …

Cortical induction of c-fos by intrastriatal endothelin-1 is mediated via NMDA receptors

AM Sullivan, DS Reynolds, KL Thomas, AJ Morton - Neuroreport, 1996 - journals.lww.com
ENDOTHELIN (ET) is a potent vasoconstrictor which has also been proposed to act as a
neuromodulator. We have investigated the action of ET-1 on neurones in vivo, using c-fos as …

Endothelin-1–induced spreading depression in rats is associated with a microarea of selective neuronal necrosis

JP Dreier, J Kleeberg, M Alam, S Major… - Experimental …, 2007 - journals.sagepub.com
Two different theories of migraine aura exist: In the vascular theory of Wolff, intracerebral
vasoconstriction causes migraine aura via energy deficiency, whereas in the neuronal …