Infarcts of the neonatal cerebral cortex can lead to progressive epilepsy, which is
characterized by time-dependent increases in seizure frequency after the infarct and by …

We have described the binding of [125 I] endothelin-1 (ET-1) to cultured rat cerebellar
granule cells. Binding of [125 I] ET-1 was specific, saturable, and time-dependent. Scatchard …

Under pathological conditions such as ischemia (I), subarachnoid hemorrhage, and Alzhei¬
mer's disease, astrocytes show a large increase in endo¬ thelin (ET)‐like immunoreactivity …

Endothelin-mediated vasoconstriction may theoretically aggravate ischemic neuronal
damage. Although investigators have demonstrated that endothelins are produced by …

We characterized the time-course, intensity of expression and cellular origin of components
of the endothelin (ET) system in the rat brain after a standardized neurotrauma (cryogenic …

These investigations characterised the cerebrovascular effects of an endothelin ETA-
receptor antagonist PD156707 in normal and ischaemic cat brain. A dose of PD156707 that …

The recently described family of proteins, the endothelins, are produced in neurons and bind
to extravascular sites in the CNS. To characterize these receptors, we carried out studies on …

The role of endothelin receptor subtypes, ie, ETA and ETB receptors, in the behavioral
effects of the intracerebroventricular (ICV) administration of endothelin-1 were examined in …

We examined the possibility of the involvement of endothelin (ET)‐1, a potent vasoactive
peptide, in the process of astrocyte proliferation after brain injury. Acute brain damage in rats …

We presented the following results of our experimental studies performed for testifying the
possibility that ET-1 may participates in the genesis of cerebral vasospasm:(1) ET-1 induced …