[HTML][HTML] Human organotypic airway and lung organoid cells of bronchiolar and alveolar differentiation are permissive to infection by influenza and SARS-CoV-2 …

CT Ekanger, F Zhou, D Bohan, ML Lotsberg… - Frontiers in cellular …, 2022 - frontiersin.org
The ongoing coronavirus disease 2019 (COVID-19) pandemic has led to the initiation of
unprecedented research efforts to understand the pathogenesis mediated by Severe Acute …

Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection

R Pei, J Feng, Y Zhang, H Sun, L Li, X Yang, J He… - Protein & …, 2021 - academic.oup.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic is caused by infection with
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is spread …

Human nasal organoids model SARS-CoV-2 upper respiratory infection and recapitulate the differential infectivity of emerging variants

MC Chiu, C Li, X Liu, W Song, Z Wan, Y Yu, J Huang… - MBio, 2022 - Am Soc Microbiol
The human upper respiratory tract, specifically the nasopharyngeal epithelium, is the entry
portal and primary infection site of respiratory viruses. Productive infection of SARS-CoV-2 in …

A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant

MC Chiu, C Li, X Liu, Y Yu, J Huang, Z Wan, D Xiao… - Cell discovery, 2022 - nature.com
The airways and alveoli of the human respiratory tract are lined by two distinct types of
epithelium, which are the primary targets of respiratory viruses. We previously established …

An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells

MM Lamers, J van Der Vaart, K Knoops… - The EMBO …, 2021 - embopress.org
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes coronavirus
disease 2019 (COVID‐19), which may result in acute respiratory distress syndrome (ARDS) …

Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19

C Tindle, MK Fuller, A Fonseca, S Taheri… - Elife, 2021 - elifesciences.org
Background: SARS-CoV-2, the virus responsible for COVID-19, causes widespread damage
in the lungs in the setting of an overzealous immune response whose origin remains …

Induced pluripotent stem cells (iPSCs) derived 3D human lung organoids from different ethnicities to understand the SARS-CoV2 severity/infectivity percentage

B Bose - Stem cell reviews and reports, 2021 - Springer
The SARS-CoV2 pandemic has indeed shrugged the entire world, changing the lifestyle and
social interaction of people to a bare minimum. Despite the stringent measures, the …

Impact of changes in human airway epithelial cellular composition and differentiation on SARS-CoV-2 infection biology

M Thaler, Y Wang, AM van der Does, A Faiz… - Journal of Innate …, 2023 - karger.com
The consequences of infection with severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) can range from asymptomatic to fatal disease. Variations in epithelial susceptibility to …

[HTML][HTML] Actionable cytopathogenic host responses of human alveolar type 2 cells to SARS-CoV-2

RM Hekman, AJ Hume, RK Goel, KM Abo, J Huang… - Molecular cell, 2020 - cell.com
Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
causative pathogen of the COVID-19 pandemic, exerts a massive health and socioeconomic …

The transcriptome landscape of the in vitro human airway epithelium response to SARS-CoV-2

S Assou, E Ahmed, L Morichon, A Nasri… - International Journal of …, 2023 - mdpi.com
Airway–liquid interface cultures of primary epithelial cells and of induced pluripotent stem-
cell-derived airway epithelial cells (ALI and iALI, respectively) are physiologically relevant …