The molecular origin of the BCR-ABL chimeric gene is now reasonably well defined; a new
breakpoint cluster region in the BCR gene, designated [mu]-bcr, has recently been …

Amplification of the bcr‐abl fusion gene has recently been associated with resistance to
imatinib therapy in chronic myeloid leukemia (CML). A 55‐yr‐old man was diagnosed with …

PURPOSE: A small proportion of patients with chronic myeloid leukemia (CML) achieve a
complete cytogenetic response (CCR), defined as the disappearance of Philadelphia (Ph) …

The use of the real-time reverse-transcription polymerase-chain reaction (RT-PCR) method
to quantify BCR-ABL transcripts before and after allogeneic transplant was prospectively …

The Incidence and Patterns of BCR/ABL Rearrangements in Chronic Myeloid Leukaemia (CML)
Using Fluorescence In situ Hybridisation Page 1 October 2005, Vol. 34 No. 9 533 FISH Patterns …

We have used a new single‐step real‐time reverse transcription polymerase chain reaction
(RT‐PCR) method to quantify BCR‐ABL transcripts, thereby estimating the relapse stage in …

Purpose Chronic myeloid leukemia (CML) patients are monitored by both cytogenetic and
molecular assessments, although present guidelines appear to switch from cytogenetic to …

The degree of tumor load reduction after therapy, which is determined by the degrees of
cytoreduction and cytogenetic response, is an important prognostic factor for patients with …

The BCR-ABL gene rearrangement, the initial event in the development of chronic myeloid
leukemia, primarily produces clonal expansion in CML by blocking apoptosis, a genetically …