FLUID SECRETION INTO THE DEVELOPING lungs' air spaces is essential for normal lung
development, but this fluid must be cleared at birth so that effective gas exchange can occur …

Late in gestation, the developing air space epithelium switches from chloride and fluid
secretion to sodium and fluid absorption. Absorption requires Na-K-ATPase acting in …

The Na+ pump, Na+-K+-ATPase, along with the Na+ channel is essential for the removal of
alveolar solute and fluid perinatally. Because Na+-pump mRNA and activity increase before …

Significant progress have been made in understanding the mechanisms of alveolar fluid
clearance at the time of birth and the transition from placental oxygenation to air breathing …

Late in gestation, the prenatal fetal alveolar epithelium switches from fluid secretion to
resorption of salt and water via apical sodium channels and basal Na-K-ATPase. The …

Glucocorticoid hormones play an important role in fetal lung maturation. It is unknown how
they interact with changes in O2 tension, which play an important role in converting the lung …

Late in gestation lung epithelium changes from net chloride and fluid secretion to sodium
and fluid absorption. Fluid resorption is required for postnatal gas exchange and occurs by …

Lung epithelial ion transport promotes salt and water movement across the fetal and
neonatal lung epithelium. The mechanism is dependent on basolateral membrane Na-K …

Na-K-ATPase protein is critical for maintaining cellular ion gradients and volume and for
transepithelial ion transport in kidney and lung. Thyroid hormone, 3, 3′, 5-triiodo-l …

Glucocorticoid and thyroid hormones (T3) are important for the development of the lungs'
Na+ absorbing phenotype, which is essential for the integrated functioning of the respiratory …