abstract Background: The role of interleukin (IL)-23 in asthma pathophysiology is still
controversial. We examined its role in allergic airway inflammation in response to two …

Background: Interleukin (IL)-23/Th17 axis plays an important role in the pathophysiology of
asthma and eczema, however, there are some conflicting data about the effects of this …

BACKGROUND: IL-22 functions as both a proinflammatory cytokine and an anti-
inflammatory cytokine in various inflammations, depending on the cellular and cytokine …

Nonallergic eosinophilic asthma (NAEA) is a clinically distinct subtype of asthma. Thus far,
the pathophysiologic mechanisms underlying NAEA have not been fully elucidated. This …

Asthma is a chronic airway inflammatory disease characterized by intense leukocyte and
eosinophilic infiltration accompanied by mucus hypersecretion and tissue …

Rationale: IL-22 has both proinflammatory and antiinflammatory properties. Its role in
allergic lung inflammation has not been explored. Objectives: To investigate the expression …

Abstract T helper 2 (Th2) cells induce allergic inflammation through the production of
cytokines such as interleukin (IL)-4, IL-5 and IL-13. Recently, it has been demonstrated that …

Interleukin 23 and the interleukin 23 receptor (IL-23-IL23R) are described as the major
enhancing factors for Interleukin 17 (IL-17) in allergic airway inflammation. IL-17 is …

Asthma is a chronic inflammatory disease of the airways that is characterized by eosinophilic
inflammation, mucus hypersecretion and airway remodeling that leads to airway obstruction …

IL-22 is a Th17/Th22 cytokine that is increased in asthma. However, recent animal studies
showed controversial findings in the effects of IL-22 in allergic asthma. To determine the role …