Hypoxia is an important component of the tumor microenvironment and has been the target
of drug discovery efforts for almost half a century. These efforts have evolved from offsetting …

In recent years, there has been great progress in the understanding of tumor biology and its
surrounding microenvironment. Solid tumors create regions with low oxygen levels …

Tumor hypoxia is a physiologic barrier to radiotherapy and anti-tumor drug delivery.
Numerous efforts have been made to overcome this barrier and to improve therapeutic …

The tumor microenvironment is now recognized as a major factor that influences not only the
response to conventional anti-cancer therapies but also helps define the potential for …

Solid tumours contain regions at very low oxygen concentrations (hypoxia), often
surrounding areas of necrosis. The cells in these hypoxic regions are resistant to both …

Hypoxia is arguably the first recognized cancer microenvironment hallmark and affects
virtually all cellular populations present in tumors. During the past decades the complex …

Abstract Hypoxia (oxygen levels below 1–2%) is a common finding in solid tumors. The
development of tumor hypoxia can be viewed as an imbalance between oxygen supply and …

Hypoxia exerts a profound impact on diverse aspects of cancer biology. Increasing evidence
has revealed novel functions of hypoxia in cancer cell epigenomics, epitranscriptomics …

Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

Tumor hypoxia has long been recognized as a critical issue in oncology. Resistance of
hypoxic areas has been shown to affect treatment outcome after radiation, chemotherapy …