Background Spinal cord injury (SCI) is a devastating disease, which results in tissue loss
and neurologic dysfunction. NLRP3 inflammasome plays an important role in the …

Spinal cord injury (SCI) is a serious condition that affects bodily function; however, there is
no effective therapy in clinical practice. MCC950, a selective NOD-like receptor protein-3 …

Background Nod-like receptor protein 3 (NLRP3) inflammasome is a crucial factor in
mediating inflammatory responses after cerebral ischemia/reperfusion (I/R), but the cellular …

The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain
containing 3 (NLRP3) inflammasome-mediated inflammatory response has emerged as a …

Intracerebral hemorrhage (ICH) is the most fatal subtype of stroke; there is still a lack of
effective treatment. Microglia are a major component of the innate immune system, and they …

Background Previous studies reported that URB597 (URB) had therapeutic potential for
treating chronic cerebral hypoperfusion (CCH)-induced neuroinflammation and autophagy …

Background Neuroinflammation is an essential player in many neurological diseases
including traumatic brain injury (TBI). Recent studies have identified that inflammasome …

Inflammation in the brain accompanies several high-impact neurological diseases including
multiple sclerosis (MS), stroke, and Alzheimer's disease. Neuroinflammation is sterile, as …

The NLRP3 inflammasome signaling pathway is a major contributor to the
neuroinflammatory process in the central nervous system. Oxidative stress and …

Traumatic brain injury (TBI), an acquired brain injury imparted by a mechanical trauma to the
head, has significant ramifications in terms of long-term disability and cost of healthcare. TBI …