Interferons (IFNs) were discovered over a half-century ago as antiviral factors. The role of
type I IFNs has been studied in the pathogenesis of both acute and chronic microbial …

Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes Page 1
Leading Edge Minireview Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse …

Defense against bacterial infections requires activation of the immune response as well as
timely reestablishment of tissue and immune homeostasis. Instauration of homeostasis is …

Interferons (IFNs) are a broad class of cytokines that have multifaceted roles. Type I IFNs
have variable effects when it comes to host susceptibility to bacterial infections, that is, the …

Summary Type I interferons (IFN-Is) are fundamental for antiviral immunity, but their role in
bacterial infections is contradictory and incompletely described. Streptococcus pyogenes …

The innate immune system possesses a multitude of pathways to sense and respond to
microbial pathogens. One such family are the interferons (IFNs), a family of cytokines that …

Type I IFNs are known to inhibit viral replication and mediate protection against viral
infection. However, recent studies revealed that these cytokines play a broader and more …

Highlights•IFN-I signaling has recently been shown to contribute to viral immune
pathologies.•Elevated IFN-I signatures are found in persistent virus infections in multiple …

Type I interferons (IFNs) are pleiotropic cytokines well recognized for their role in the
induction of a potent antiviral gene program essential for host defense against viruses. They …

Abstract Since Isaac's and Lindenmann's seminal experiments over 50 years ago
demonstrating a soluble factor generated from heat killed virus-stimulated chicken embryos …